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RU2708683C2_CRYSTALLINE SALT OF NINTEDANIB DIETHANESULFONATE AND METHOD FOR PRODUCTION AND USE THEREOF

专利基本信息
申请号RU2017136104申请日2016-03-11
公开(公告)号RU2708683C2公开(公告)日2019-12-11
申请公布号RU2708683C2申请公布日2019-12-11
分类号C07D209/34;A61K31/496;A61P11/00;A61P35/00;A61P37/00分类有机化学〔2〕
发明人-申请(专利权)人
ЧИА ТАЙ ТЯНЬЦИН ФАРМАСЬЮТИКАЛ ГРУП КО., ЛТД.
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
代理机构-代理人-
地址-
摘要FIELD: chemistry.SUBSTANCE: present invention relates to crystalline salt of nintedanib diethanesulfonate of A-type represented by formula (II), and also relates to a crystalline composition and a pharmaceutical composition containing a crystal, and to a method for production and use thereof. X-ray powder diffractometry spectrum of the crystalline nintedanib salt of diethanesulfonate of the present invention is characterized by diffraction peaks at approximately 14.64, 18.79, 19.31, 20.11, 21.20, 22.45 and 26.71°, if presented in values 2θ.EFFECT: crystalline nintedanib diethanesulfonate salt of the present invention is characterized by resistance, is non-hygroscopic and difficult to decompose, and is most suitable for medical production.18 cl, 2 dwg, 3 tbl, 4 ex
CRYSTALLINE SALT OF NINTEDANIB DIETHANESULFONATE AND METHOD FOR PRODUCTION AND USE THEREOF
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