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WO2020124688A1_FULL-SPECTRUM HIGH-BRIGHTNESS AND HIGH-STABILITY FLUORESCENT DYES, AND SYNTHESIS AND APPLICATION THEREOF

专利基本信息
申请号WOCN19000193申请日2019-10-10
公开(公告)号WO2020124688A1公开(公告)日2020-06-25
申请公布号WO2020124688A1申请公布日2020-06-25
分类号C09K11/06;C07D221/14;C07D473/18;G01N21/64;C07K1/13分类染料;涂料;抛光剂;天然树脂;黏合剂;其他类目不包含的组合物;其他类目不包含的材料的应用
发明人XU, Zhaochao;QIAO, Qinglong;ZHOU, Wei申请(专利权)人
DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
代理机构
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沈阳晨创科技专利代理有限责任公司;SHENYANG CHENCHUANG TECHNICAL PATENT AGENT LTD代理人
专利代理师是代理他人进行专利申请和办理其他专利事务,取得一定资格的人。专利代理师应具备一定的条件,经考核批准,由国家知识产权局颁发专利代理师资格证。
沈阳晨创科技专利代理有限责任公司;SHENYANG CHENCHUANG TECHNICAL PATENT AGENT LTD
地址DU, Wei, No.457 Zhongshan Road, Shahekou District, Dalian, Liaoning 116023 116023 CN
摘要Provided in the present invention are full-spectrum high-brightness and high-stability fluorescent dyes, the dyes being one or several of the following mixed according to any ratio: 4-amido substituted naphthalimide dye, bisalkoxy substituted naphthalimide fluorescent dye, bisamino substituted naphthalimide fluorescent dye, 9, 10-bisamino substituted perylene imide, six-membered ring rhodamine dye, five-membered ring rhodamine dye, and silicon-based rhodamine dye. Compared to current commercial dyes, the fluorescent dyes of the present invention have higher photostability and narrower full width at half maximum (25 nm), and are not sensitive to various external environments including pH, polarity, and temperature. By means of the introduction of active groups such as click groups, protein tags, and drug molecules, the obtained functionalised fluorescent molecules have high biocompatibility, and can quickly and specifically dye living cells and bodies. Due to the increased photostability and fluorescent brightness, the present series of dyes can implement super-resolution fluorescence imaging in Storm, STED, and SIM modes.
FULL-SPECTRUM HIGH-BRIGHTNESS AND HIGH-STABILITY FLUORESCENT DYES, AND SYNTHESIS AND APPLICATION THEREOF
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